Graham P Holloway Selected Research

Glucose Intolerance

1/2022	Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1.
1/2021	Independent of mitochondrial respiratory function, dietary nitrate attenuates HFD-induced lipid accumulation and mitochondrial ROS emission within the liver.
1/2020	Nitrate attenuates high fat diet-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission.
6/2017	The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.
4/2016	LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition.
1/2016	Prior exercise training blunts short-term high-fat diet-induced weight gain.
1/2016	Combined high-fat-resveratrol diet and RIP140 knockout mice reveal a novel relationship between elevated bone mitochondrial content and compromised bone microarchitecture, bone mineral mass, and bone strength in the tibia.
10/2015	Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats.
8/2014	AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.

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Graham P Holloway Research Topics

Disease

30	Insulin Resistance 01/2022 - 06/2007
12	Obesity 01/2022 - 06/2007
10	Type 2 Diabetes Mellitus (MODY) 11/2021 - 10/2009
9	Glucose Intolerance 01/2022 - 08/2014
3	Inflammation (Inflammations) 01/2020 - 01/2020
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2018 - 01/2011
3	Fibrosis (Cirrhosis) 01/2017 - 06/2014
2	Fatigue 01/2022 - 11/2019
2	Hyperlipidemias (Hyperlipidemia) 01/2021 - 08/2015
2	Weight Gain 01/2021 - 01/2016
2	Heart Failure 01/2020 - 01/2011
2	Body Weight (Weight, Body) 01/2020 - 04/2015
1	Hyperglycemia 11/2021
1	Fatty Liver 01/2021
1	Cardiomyopathies (Cardiomyopathy) 01/2020
1	Hyperphagia (Overeating) 01/2020
1	Hypertrophy 01/2020
1	Infarction (Infarctions) 01/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Hemorrhage 01/2018
1	Leukemia 01/2018
1	Lymphoma (Lymphomas) 01/2018
1	Multiple Myeloma 01/2018
1	Neoplasms (Cancer) 01/2018
1	Thrombocytopenia (Thrombopenia) 01/2018
1	Hematologic Neoplasms (Hematological Malignancy) 01/2018
1	Liver Diseases (Liver Disease) 01/2017
1	Muscular Atrophy (Muscle Atrophy) 10/2016
1	Bone Resorption 01/2016
1	Dyspnea (Shortness of Breath) 10/2015
1	Atrophy 10/2015
1	Reperfusion Injury 02/2015
1	Diabetic Cardiomyopathies 06/2014
1	Metabolic Diseases (Metabolic Disease) 04/2010

Drug/Important Bio-Agent (IBA)

17	Fatty Acids (Saturated Fatty Acids)IBA 04/2016 - 06/2007
15	LipidsIBA 11/2021 - 06/2007
9	Adenosine Diphosphate (ADP)IBA 01/2022 - 12/2013
8	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 02/2013
8	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 12/2013
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2008
7	Insulin (Novolin)FDA Link 01/2022 - 10/2015
5	NitratesIBA 01/2022 - 01/2018
4	PalmitatesIBA 06/2011 - 06/2007
3	Palmitoyl Coenzyme A (Palmitoyl CoA)IBA 11/2018 - 06/2014
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 04/2016 - 10/2010
3	ResveratrolIBA 01/2016 - 12/2013
3	Coenzyme A (CoA)IBA 08/2015 - 11/2012
3	Triglycerides (Triacylglycerol)IBA 08/2014 - 04/2009
2	Biological ProductsIBA 11/2021 - 01/2020
2	AntioxidantsIBA 01/2021 - 05/2015
2	Acetyl-CoA CarboxylaseIBA 01/2021 - 08/2014
2	Blood Glucose (Blood Sugar)IBA 01/2020 - 06/2014
2	Linoleic Acid (Linoleate)IBA 04/2016 - 07/2014
2	alpha-Linolenic Acid (Linolenic Acid)IBA 04/2016 - 07/2014
2	EnzymesIBA 10/2015 - 05/2015
2	CatalaseIBA 05/2015 - 02/2015
2	CeramidesIBA 08/2014 - 04/2014
2	Transcription Factors (Transcription Factor)IBA 01/2009 - 06/2008
2	PPAR alphaIBA 01/2009 - 06/2008
2	PPAR deltaIBA 01/2009 - 06/2008
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2022
1	AMP-Activated Protein KinasesIBA 01/2021
1	Pyruvic Acid (Pyruvate)IBA 01/2020
1	Drinking WaterIBA 01/2020
1	JNK Mitogen-Activated Protein KinasesIBA 01/2020
1	sodium nitrateIBA 01/2020
1	rab GTP-Binding ProteinsIBA 01/2020
1	Succinic Acid (Succinate)IBA 01/2020
1	Adenosine Triphosphatases (ATPase)IBA 11/2019
1	Oxygen (Dioxygen)IBA 01/2019
1	Hemostatics (Antihemorrhagics)IBA 01/2018
1	O(4)-methylthymidine triphosphateIBA 01/2017
1	ApolipoproteinsIBA 01/2017
1	Lipoproteins (Lipoprotein)IBA 01/2017
1	microsomal triglyceride transfer proteinIBA 01/2017
1	Cathepsin KIBA 01/2016
1	MineralsIBA 01/2016
1	sarcolipinIBA 12/2015
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 10/2015
1	MyostatinIBA 10/2015
1	Malonyl Coenzyme A (Malonyl CoA)IBA 08/2014
1	Therapeutic UsesIBA 07/2014
1	DiglyceridesIBA 04/2014
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 11/2012
1	Interleukin-6 (Interleukin 6)IBA 01/2012
1	mitochondrial transcription factor AIBA 01/2009
1	PPAR gammaIBA 06/2008
1	Dynamins (Dynamin)IBA 06/2008

Therapy/Procedure

3	Bed Rest (Bedrest) 01/2020 - 10/2016
1	Caloric Restriction 01/2020
1	Drug Therapy (Chemotherapy) 01/2018
1	Endurance Training 01/2017
1	Therapeutics 01/2017
1	Physical Therapy Modalities (Physical Therapy Technique) 10/2015